ARL6IP5 antibody (HRP)

Catalog No. ABIN1422076

This Rabbit Polyclonal antibody specifically detects ARL6IP5 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ARL6IP5 antibody (HRP) (ABIN1422076)

Target: ARL6IP5 (Arl6ip5) (ADP-Ribosylation-Like Factor 6 Interacting Protein 5 (Arl6ip5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARL6IP5 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ARL6IP5 Antibody (HRP)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human JWA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ARL6IP5

Target: ARL6IP5 (Arl6ip5) (ADP-Ribosylation-Like Factor 6 Interacting Protein 5 (Arl6ip5))

Alternative Name: JWA

Background:

Synonyms: Addicsin, ADP ribosylation like factor 6 interacting protein 5, Aip 5, Aip5, ARL 6 interacting protein 5, ARL6IP5 antibody Cytoskeleton related vitamin A responsive protein, Dermal papilla derived protein 11, DERP 11, DERP11, Glutamate transporter EEAC 1 associated protein, Glutamate transporter EEAC1 associated protein, GTRAP3 18, Hp 22, Hp22, HSPC 127, HSPC127, JM 5, JM5, JMX, PRA 1 domain family 3, PRA 2, PRA1 domain family 3, PRA2, PRAF 3, PRAF3, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK activating protein PM27, PRAF3_HUMAN.

Background: JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals.

Gene ID: 10550

Pathways: Dicarboxylic Acid Transport