ANKRD20A3 antibody (HRP)

Catalog No. ABIN1422304

This Rabbit Polyclonal antibody specifically detects ANKRD20A3 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for ANKRD20A3 antibody (HRP) (ABIN1422304)

Target: ANKRD20A3 (Ankyrin Repeat Domain 20 Family, Member A3 (ANKRD20A3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD20A3 antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ANKRD20A3 Antibody (HRP)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANKRD20A3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ANKRD20A3

Target: ANKRD20A3 (Ankyrin Repeat Domain 20 Family, Member A3 (ANKRD20A3))

Alternative Name: ANKRD20A3

Background:

Synonyms: Ankyrin repeat domain 20 family member A3, Ankyrin repeat domain 20A related, Ankyrin repeat domain containing protein 20A3, MGC176486, MGC198508, A20A3_HUMAN.

Background: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein that contains five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and familial dysautonomia are associated with chromosome 9. Also, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.

Gene ID: 441425