Neuroligin 2 antibody (PE-Cy5)

Catalog No. ABIN1424807

The Rabbit Polyclonal anti-Neuroligin 2 antibody has been validated for FACS. It is suitable to detect Neuroligin 2 in samples from Human, Rat, Mouse, Dog, Cow, Horse, Pig and Rabbit.

Quick Overview for Neuroligin 2 antibody (PE-Cy5) (ABIN1424807)

Target: Neuroligin 2 (NLGN2)

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuroligin 2 antibody is conjugated to PE-Cy5

Application: Flow Cytometry (FACS)

Product Details anti-Neuroligin 2 Antibody (PE-Cy5)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NLGN2

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for Neuroligin 2

Target: Neuroligin 2 (NLGN2)

Alternative Name: NLGN2

Background:

Synonyms: NL1, NL2, Neuroligin 1, Neuroligin 2, Neuroligin I, Ortholog of human and rat neuroligin 2 NLGN2, NLGN2_HUMAN.

Background: Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.

Molecular Weight: 90kDa

Gene ID: 57555

Pathways: Cell-Cell Junction Organization, Synaptic Membrane