Neurexin 2 (NRXN2) antibody (PE)

Catalog No. ABIN1424835

Product Details

Target: Neurexin 2 (NRXN2)

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: PE

Application: Please inquire

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neurexin 2

Isotype: IgG

Application Details

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4°C

Expiry Date: 12 months

Target Details

Target: Neurexin 2 (NRXN2)

Alternative Name: Neurexin 2 (NRXN2 Products)

Background:

Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.

Subcellular location: Extracellular

Synonyms: Neurexin 2, Neurexin-2, Neurexin2, Neurexin II, Neurexin II alpha, NRXN 2, NRXN-2, NRXN2, NRX2A_HUMAN.

Pathways: Synaptic Membrane