LRRTM1 antibody (PE-Cy5)

Catalog No. ABIN1425377

The Rabbit Polyclonal anti-LRRTM1 antibody has been validated for WB. It is suitable to detect LRRTM1 in samples from Human, Mouse, Rat, Cow, Dog, Pig and Chicken.

Quick Overview for LRRTM1 antibody (PE-Cy5) (ABIN1425377)

Target: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM1 antibody is conjugated to PE-Cy5

Application: Western Blotting (WB)

Product Details anti-LRRTM1 Antibody (PE-Cy5)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRRTM1

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LRRTM1

Target: LRRTM1 (Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1))

Alternative Name: LRRTM1

Background:

Synonyms: Leucine rich repeat transmembrane neuronal 1, Leucine rich repeat transmembrane neuronal 1 protein, Leucine-rich repeat transmembrane neuronal protein 1, LRRT1_HUMAN, LRRTM1, Lrrtm1 leucine rich repeat transmembrane neuronal 1, OTTHUMP00000194829, 4632401D06Rik, AW125451, FLJ32082.

Background: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRTM1 (leucine rich repeat transmembrane neuronal 1) is a 522 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and contains ten LRR repeats. Expressed predominately in forebrain tissue, LRRTM1 is thought to be involved in the development of forebrain structures, specifically by influencing axon trafficking, as well as neuronal differentiation and connectivity. Human LRRTM1 shares 96 % amino acid identity with its mouse counterpart, suggesting a conserved role between species. Defects in the gene encoding LRRTM1 may be associated with the pathogenesis of several common neurodevelopmental disorders.

Molecular Weight: 59kDa

Pathways: Synaptic Membrane