AVPR1B antibody (PE-Cy5.5)

Catalog No. ABIN1428258

This anti-AVPR1B antibody is a Rabbit Polyclonal antibody detecting AVPR1B in WB. Suitable for Human, Rat, Mouse, Dog, Cow and Pig.

Quick Overview for AVPR1B antibody (PE-Cy5.5) (ABIN1428258)

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Reactivity: Human, Rat, Mouse, Dog, Cow, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR1B antibody is conjugated to PE-Cy5.5

Application: Western Blotting (WB)

Product Details anti-AVPR1B Antibody (PE-Cy5.5)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AVP Receptor V3

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AVPR1B

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Alternative Name: AVPR1B/AVP Receptor V3

Background:

Synonyms: Antidiuretic hormone receptor 1b, Arginine vasopressin receptor 1B, Arginine vasopressin receptor 3, AVPR V1b, AVPR V3, Avpr1b, AVPR3, Pituitary vasopressin receptor 3, V1bR, V1BR_HUMAN, Vasopressin V1b receptor, Vasopressin V3 receptor, VPR3.

Background: Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality (1-3). AVP mediates its effects through a family of G-protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b) (1,2). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion (3). It is detected as a full length protein and a shorter protein, which results from proteolytic cleavage of its amino terminus (4). The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration (3). The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney (5,6). Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP (5,7). The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system (7). The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores (8). AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors (2).

Molecular Weight: 47kDa

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones