MARCH9 antibody (PE)

Catalog No. ABIN1435557

This anti-MARCH9 antibody is a Rabbit Polyclonal antibody detecting MARCH9 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for MARCH9 antibody (PE) (ABIN1435557)

Target: MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARCH9 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-MARCH9 Antibody (PE)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MARCH9

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MARCH9

Target: MARCH9 (Membrane-Associated Ring Finger (C3HC4) 9 (MARCH9))

Alternative Name: MARCH9

Background:

Synonyms: E3 ubiquitin protein ligase MARCH9, MARCH IX, Membrane associated RING CH protein IX, membrane associated ring finger C3HC4 9, Membrane associated RING finger protein 9, RING finger protein 179, RNF179, MARH9_HUMAN.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.

Gene ID: 92979