CD8 antibody

Catalog No. ABIN1449140

Product Details anti-CD8 Antibody

Target: CD8

Reactivity: Sheep, Cow, Goat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity Chromatography on Protein G

Clone: CC63

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References for anti-CD8 antibody (ABIN1449140)

Lynch, Earley, McGee, Doyle: "Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves." in: BMC veterinary research, Vol. 6, pp. 39, (2010) (PubMed).

Coad, Clifford, Rhodes, Hewinson, Vordermeier, Whelan: "Repeat tuberculin skin testing leads to desensitisation in naturally infected tuberculous cattle which is associated with elevated interleukin-10 and decreased interleukin-1 beta responses." in: Veterinary research, Vol. 41, Issue 2, pp. 14, (2009) (PubMed).

Sidders, Pirson, Hogarth, Hewinson, Stoker, Vordermeier, Ewer: "Screening of highly expressed mycobacterial genes identifies Rv3615c as a useful differential diagnostic antigen for the Mycobacterium tuberculosis complex." in: Infection and immunity, Vol. 76, Issue 9, pp. 3932-9, (2008) (PubMed).

Fulton, Portella, Radke: "Dissemination of bovine leukemia virus-infected cells from a newly infected sheep lymph node." in: Journal of virology, Vol. 80, Issue 16, pp. 7873-84, (2006) (PubMed).

Harris, Werling, Koss, Monaghan, Taylor, Howard: "Expression of caveolin by bovine lymphocytes and antigen-presenting cells." in: Immunology, Vol. 105, Issue 2, pp. 190-5, (2002) (PubMed).

Twizere, Kerkhofs, Burny, Portetelle, Kettmann, Willems: "Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo." in: Journal of virology, Vol. 74, Issue 21, pp. 9895-902, (2000) (PubMed).

Winkler, Doster, Jones: "Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves." in: Journal of virology, Vol. 74, Issue 11, pp. 5337-46, (2000) (PubMed).

Gross, Callas, Allison: "Identification and distribution of the costimulatory receptor CD28 in the mouse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 2, pp. 380-8, (1992) (PubMed).

Target Details for CD8

Target: CD8

Alternative Name: CD8 (CD8 Products)

Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2