ES1 Protein Homolog (AA 1-281), (full length), (N-Term) antibody

Catalog No. ABIN1449175

This Rat Monoclonal antibody specifically detects ES1 Protein Homolog in IF, IHC (p), IP and WB. It exhibits reactivity toward Rat.

Quick Overview for ES1 Protein Homolog (AA 1-281), (full length), (N-Term) antibody (ABIN1449175)

Target: ES1 Protein Homolog

Reactivity: Rat

Host: Rat

Clonality: Monoclonal

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Clone: NM1

Product Details

Binding Specificity: AA 1-281, full length, N-Term

Specificity: This antibody reacts with rat HES1.

Purification: Protein G agarose

Immunogen: Full-length rat HES1 (1-281 aa)

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details

Target: ES1 Protein Homolog

Background: Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I

Gene ID: 294326

NCBI Accession: NP_001004225

UniProt: P56571