ATP1A1 antibody

Catalog No. ABIN1449189

The Mouse Monoclonal anti-ATP1A1 antibody (Clone 9A7) (ABIN1449189) specifically detects ATP1A1 in WB and IF. The antibody is reactive with Human and Rat samples.

Quick Overview for ATP1A1 antibody (ABIN1449189)

Target: ATP1A1 (Sodium Potassium ATPase, alpha1 (ATP1A1))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATP1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 9A7

Product Details anti-ATP1A1 Antibody

Specificity: This antibody reacts with human Na+/K+ ATPase α subunit.

Purification: Protein A agarose

Immunogen: Chicken brain synaptic membrane

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for ATP1A1

Target: ATP1A1 (Sodium Potassium ATPase, alpha1 (ATP1A1))

Alternative Name: ATP1A1

Background: Na+/K+-ATPase is an integral membrane protein complex that is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. Na+/K+-ATPase hydrolyzes ATP to maintain the transmembrane gradients of Na+ and K+. The Na+/K+-ATPase consists of a large transmembrane catalytic subunit, termed the a subunit, and an associated smaller glycoprotein, termed the ß subunit, that appears to be necessary for the assembly and transport of the sodium pump to the plasma membrane. There are three isoforms of the a subunit (a-1, -2, and -3) and two isoforms of the ß subunit (ß-1 and -2) encoded by two multigene families. The a-1 and ß mRNAs are present in all cell types examined, whereas the a-2 and a-3 mRNAs exhibit a more restricted pattern of cell-specific expression. The a subunit protein has been found in kidney, brain (both neuronal and non-neuronal cells), heart, and to a lesser extent liver, skeletal and smooth muscle.Synonyms: Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-1

Molecular Weight: 80 kDa

Gene ID: 476

NCBI Accession: NP_000692

UniProt: P05023

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Proton Transport, Ribonucleoside Biosynthetic Process