DLK1 antibody

Catalog No. ABIN1449213

This anti-DLK1 antibody is a Rat Monoclonal antibody detecting DLK1 in FACS, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for DLK1 antibody (ABIN1449213)

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This DLK1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 24-11-14

Product Details anti-DLK1 Antibody

Specificity: This antibody reacts with Dlk.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Protein G Agarose Chromatography of hybridoma supernatant

Immunogen: Pref-1-Fc protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % Glycerol, pH 7.2, None

Preservative: Azide free

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for DLK1

Target: DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))

Alternative Name: DLK1

Background: Delta like protein (Dlk), also known as Preadipocyte factor-1 (Pref-1) or zona glomerulosa-specific factor (ZOG), is an EGF-like transmembrane protein expressed preadipocytes but not in mature adipocytes. It is highly expressed in fetal liver, the adrenal gland, and placenta, as well as some neuroendocrine tumors and small cell lung carcinomas, where it plays a role in differentiation and proliferation. Dlk positively and negatively regulates adipocyte differentiation via at least four major variants (45-60 kDa) of Dlk generated by alternatively splicing. Constitutive expression of Dlk inhibits adipogenesis, but insulin or insulin like growth factor-1 (IGF-1) can circumvent this inhibition. Regulated processing of Dlk releases a 50 kDa soluble form that was previously characterized as Fetal Antigen-1, a protein involved in pancreatic island cell differentiation.Synonyms: DLK, DLK-1, PREF1, Preadipocyte factor 1, Protein delta homolog 1, pG2

Gene ID: 13386

NCBI Accession: NP_034182

UniProt: Q09163