Histone H4 antibody

Catalog No. ABIN1449238

This Mouse Monoclonal antibody specifically detects Histone H4 in WB, IF and IP. It exhibits reactivity toward Human, Mouse, Rat and Hamster.

Quick Overview for Histone H4 antibody (ABIN1449238)

Target: Histone H4

Reactivity: Human, Mouse, Rat, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This Histone H4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: C14691

Product Details anti-Histone H4 Antibody

Specificity: This antibody reacts with Histone H4.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat, Hamster

Purification: Protein A agarose

Immunogen: Protein fraction extracted from the mitotic chromosome

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for Histone H4

Target: Histone H4

Background: The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The N-terminal tail of core histones undergoes multiple different post-transcriptional modifications including acetylation, phosphorylation, ubiquitination, methylation, and ADP-ribosylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. Acetylation of histone H4 plays a primary role in the structural changes that mediate enhanced binding of transcription factors to their recognition sites within nucleosomes. It has been suggested that acetylated Histone H4 also is involved in heightened activation of the transcription of male X chromosomes, and that Histone H4 stimulates glucose transport activity in rat skeletal muscle.Synonyms: H4/A, H4FA, HIST1H4

Molecular Weight: 11 kDa

Gene ID: 121504

NCBI Accession: NP_001029249

UniProt: P62805