MORC3 antibody
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- Target See all MORC3 Antibodies
- MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))
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Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This MORC3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificity
- This antibody detects MORC3.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Mouse, Rat
- Purification
- Protein A agarose
- Immunogen
- Recombinant human MORC3
- Clone
- 17A9
- Isotype
- IgG1
- Top Product
- Discover our top product MORC3 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Upon receipt, store (in aliqouts) at -20 °C.
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- Target
- MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))
- Alternative Name
- MORC3 (MORC3 Products)
- Background
- MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
- Gene ID
- 23515
- NCBI Accession
- NP_056173
- UniProt
- Q14149
- Pathways
- Maintenance of Protein Location
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