MORC3 antibody

Catalog No. ABIN1449250

This Mouse Monoclonal antibody specifically detects MORC3 in WB and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MORC3 antibody (ABIN1449250)

Target: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MORC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 17A9

Product Details anti-MORC3 Antibody

Specificity: This antibody detects MORC3.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat

Purification: Protein A agarose

Immunogen: Recombinant human MORC3

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for MORC3

Target: MORC3 (MORC Family CW-Type Zinc Finger 3 (MORC3))

Alternative Name: MORC3

Background: MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3

Gene ID: 23515

NCBI Accession: NP_056173

UniProt: Q14149

Pathways: Maintenance of Protein Location