ICAM-3/CD50 antibody (PE)

Catalog No. ABIN1449266

The Mouse Monoclonal anti-ICAM-3/CD50 antibody has been validated for FACS. It is suitable to detect ICAM-3/CD50 in samples from Human.

Quick Overview for ICAM-3/CD50 antibody (PE) (ABIN1449266)

Target: ICAM-3/CD50 (ICAM3) (Intercellular Adhesion Molecule 3 (ICAM3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICAM-3/CD50 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: YUK2

Product Details anti-ICAM-3/CD50 Antibody (PE)

Specificity: This antibody reacts with human CD50 antigen.

Purification: Protein A agarose

Immunogen: Human myeloma cell line (RPMI8226)

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for ICAM-3/CD50

Target: ICAM-3/CD50 (ICAM3) (Intercellular Adhesion Molecule 3 (ICAM3))

Alternative Name: CD50 / ICAM3

Background: Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). ICAM-3 (CD50) is broadly expressed on leukocytes, endothelial cells, and Langerhans cells. ICAM-3 is the most important ligand for LFA-1 in the initiation of the immune response because the expression of ICAM-1 (CD54) and ICAM-2 (CD102) on resting leukocytes is very low or not at all. Previous studies suggest that ICAM-3 acts as a biologically significant molecule playing a role in HIV-1 transcription and replication, particularly in resting CD4 + T cells. It has been suggested that dendritic cell-specific ICAM grabbing nonintegrin (DC-SIGN, CD209), a C-type lectin of macrophages and DCs, is an additional ligand of ICAM-3. The interaction of DC-SIGN with ICAM-3 establishes initial contact between dendritic cells and resting T-cells during antigen presentation.Synonyms: CDw50, ICAM-3, ICAM-R, Intercellular adhesion molecule 3

Gene ID: 3385

NCBI Accession: NP_002153

UniProt: P32942