PFKM antibody (N-Term)

Catalog No. ABIN1449415

Product Details anti-PFKM Antibody

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Binding Specificity: AA 1-780, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PFKM antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Protein-A affinity chromatography

Immunogen: Recombinant Human PFKM (1-780aa) purified from E. coli

Clone: AT2F11

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate -Buffered Saline ( pH 7.4), 0.02 % Sodium Azide, 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PFKM

Target: PFKM (phosphofructokinase, Muscle (PFKM))

Alternative Name: PFKM (PFKM Products)

Background: PFKM (phosphofructokinase, muscle) is a regulatory glycolytic enzyme that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease.Synonyms: 6-phosphofructokinase muscle type, GSD7, PFK-1, PFK-A, PFK1, PFKX, Phosphofructo-1-kinase isozyme A, Phosphofructokinase 1, Phosphofructokinase-M, Phosphohexokinase

Gene ID: 5213

NCBI Accession: NP_000280

UniProt: P08237

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Warburg Effect