TAB3 antibody (N-Term)

Catalog No. ABIN1449963

The Rabbit Polyclonal anti-TAB3 antibody (ABIN1449963) specifically detects TAB3 in IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for TAB3 antibody (N-Term) (ABIN1449963)

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TAB3 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid synthetic peptide near the amino terminus of Human TAB3

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TAB3

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Alternative Name: TAB3 / MAP3K7IP3

Background: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1, upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.Synonyms: Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NF-kappa-B-activating protein 1, TAK1-binding protein 3

Gene ID: 257397

NCBI Accession: NP_690000

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades