ATG14 antibody (Middle Region)

Catalog No. ABIN1449976

This Rabbit Polyclonal antibody specifically detects ATG14 in WB, IF and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ATG14 antibody (Middle Region) (ABIN1449976)

Target: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG14 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-ATG14 Antibody

Binding Specificity: Middle Region

Purification: Affinity chromatography purified via peptide column

Immunogen: ATG14 antibody was raised against an 18 amino acid synthetic peptide near the center of Human ATG14

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ATG14

Target: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Alternative Name: ATG14 / Barkor

Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG14 is a subunit of a class III phosphatidylinositol (PtdIns) 3-kinase complex that targets the complex to the endoplasmic reticulum, the site of autophagosome formation.Synonyms: Atg14L, Beclin 1-associated autophagy-related key regulator, KIAA0831

Molecular Weight: 54 kDa

Gene ID: 22863

NCBI Accession: NP_055739

Pathways: Autophagy