WIPI1 antibody (C-Term)

Catalog No. ABIN1449977

The Rabbit Polyclonal anti-WIPI1 antibody has been validated for WB, IF and EIA. It is suitable to detect WIPI1 in samples from Human, Mouse and Rat.

Quick Overview for WIPI1 antibody (C-Term) (ABIN1449977)

Target: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WIPI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-WIPI1 Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the carboxy terminus of Human WIPI1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for WIPI1

Target: WIPI1 (WD Repeat Domain, phosphoinositide Interacting 1 (WIPI1))

Alternative Name: WIPI-1

Background: WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.Synonyms: Atg18 protein homolog, WD repeat domain phosphoinositide-interacting protein 1, WD40 repeat protein interacting with phosphoinositides of 49 kDa, WIPI1, WIPI49

Molecular Weight: 49 kDa

Gene ID: 55062

NCBI Accession: NP_060453

Pathways: Nuclear Hormone Receptor Binding, ER-Nucleus Signaling