NDFIP1 antibody (N-Term)

Catalog No. ABIN1450002

This anti-NDFIP1 antibody is a Rabbit Polyclonal antibody detecting NDFIP1 in WB and EIA. Suitable for Human and Mouse.

Quick Overview for NDFIP1 antibody (N-Term) (ABIN1450002)

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NDFIP1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-NDFIP1 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: A 19 amino acid synthetic peptide near the amino terminus of Human NDFIP1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NDFIP1

Target: NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))

Alternative Name: NDFIP1

Background: The NEDD4 family-interacting protein 1 (NDFIP1) belongs to a small group of evolutionarily conserved proteins with three transmembrane domains and is an integral Golgi membrane protein. It is a potential target for ubiquitination by the Nedd4 family of proteins. NDFIP1 is strongly expressed in surviving neurons following acute cortical brain injury, and overexpression in cultured cortical neurons increased survival following growth factor starvation, suggesting that NDFIP1 may play a role in neuronal survival. NDFIP1 and the related protein NDFIP2 are thought to interact with and regulate multiple components of the EGF and PTEN/Akt signaling pathways. Recent studies suggest that NDFIP1 may also play a role in Th17 differentiation by limiting the production of proinflammatory cytokines.Synonyms: N4WBP5, NEDD4 family-interacting protein 1, PSEC0192, PSEC0223

Molecular Weight: 24 kDa

Gene ID: 80762

NCBI Accession: NP_085048

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Negative Regulation of Transporter Activity