MEX3B antibody (Middle Region)

Catalog No. ABIN1450108

This Rabbit Polyclonal antibody specifically detects MEX3B in WB, IF and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MEX3B antibody (Middle Region) (ABIN1450108)

Target: MEX3B (Mex-3 Homolog B (MEX3B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEX3B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-MEX3B Antibody

Binding Specificity: Middle Region

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: RKHD3 antibody was raised against a 16 amino acid synthetic peptide from near the center of human RKHD3.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MEX3B

Target: MEX3B (Mex-3 Homolog B (MEX3B))

Alternative Name: MEX3B / RKHD3

Background: Rkhd3, also known as MEX3B is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd3 is thought to act as a mechanism to fine-tune mRNA regulation in early Xenopus development, and with Rkhd4, but not Rkhd1, will co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.Synonyms: KIAA2009, RING finger and KH domain-containing protein 3, RING finger protein 195, RNA-binding protein MEX3B, RNF195

Gene ID: 84206

NCBI Accession: NP_780575