DKC1 antibody (AA 245-514)

Catalog No. ABIN1512829

This Rabbit Polyclonal antibody specifically detects DKC1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for DKC1 antibody (AA 245-514) (ABIN1512829)

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-DKC1 Antibody

Binding Specificity: AA 245-514

Sequence: ELRRVRSGVM SEKDHMVTMH DVLDAQWLYD NHKDESYLRR VVYPLEKLLT SHKRLVMKDS AVNAICYGAK IMLPGVLRYE DGIEVNQEIV VITTKGEAIC MAIALMTTAV ISTCDHGIVA KIKRVIMERD TYPRKWGLGP KASQKKLMIK QGLLDKHGKP TDSTPATWKQ EYVDYSESAK KEVVAEVVKA PQVVAEAAKT AKRKRESESE SDETPPAAPQ LIKKEKKKSK KDKKAKAGLE SGAEPGDGDS DTTKKKKKKK KAKEVELVSE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 245-514 of human DKC1 (NP_001354.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Alternative Name: DKC1

Background: This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.,DKC1,CBF5,DKC,DKCX,NAP57,NOLA4,XAP101,Epigenetics & Nuclear Signaling,RNA Binding,DKC1

Molecular Weight: 47 kDa/57 kDa

Gene ID: 1736

UniProt: O60832

Pathways: Telomere Maintenance