Akirin 1 antibody (C-Term)

Catalog No. ABIN1536697

This Rabbit Polyclonal antibody specifically detects Akirin 1 in WB. It exhibits reactivity toward Human.

Quick Overview for Akirin 1 antibody (C-Term) (ABIN1536697)

Target: Akirin 1 (AKIRIN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Akirin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB25247

Product Details anti-Akirin 1 Antibody

Binding Specificity: AA 131-158, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: AKIR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for Akirin 1

Target: Akirin 1 (AKIRIN1)

Alternative Name: AKIR1

Background: The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Molecular Weight: 21867

Gene ID: 79647

NCBI Accession: NP_001129747, NP_078871

UniProt: Q9H9L7