LIN7A antibody (C-Term)

Catalog No. ABIN1536800

The Rabbit Polyclonal anti-LIN7A antibody has been validated for WB. It is suitable to detect LIN7A in samples from Human.

Quick Overview for LIN7A antibody (C-Term) (ABIN1536800)

Target: LIN7A (Lin-7 Homolog A (LIN7A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN7A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB37057

Product Details anti-LIN7A Antibody

Binding Specificity: AA 180-207, C-Term

Predicted Reactivity: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LIN7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the C-terminal region of human LIN7A.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: LIN7A Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for LIN7A

Target: LIN7A (Lin-7 Homolog A (LIN7A))

Alternative Name: LIN7A

Background: LIN7A plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Molecular Weight: 25997

Gene ID: 8825

NCBI Accession: NP_004655

UniProt: O14910

Pathways: Synaptic Membrane