Macrophage Scavenger Receptor 1 antibody (C-Term)

Catalog No. ABIN1537159

This Rabbit Polyclonal antibody specifically detects Macrophage Scavenger Receptor 1 in WB. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for Macrophage Scavenger Receptor 1 antibody (C-Term) (ABIN1537159)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Macrophage Scavenger Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB36746

Product Details anti-Macrophage Scavenger Receptor 1 Antibody

Binding Specificity: AA 336-364, C-Term

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MSR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

References for anti-Macrophage Scavenger Receptor 1 antibody (ABIN1537159)

Chen, Li, Zhu: "AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-?B/LOX-1 pathway." in: Vascular pharmacology, (2015) (PubMed).

Target Details for Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1

Background: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Molecular Weight: 49762

Gene ID: 4481

NCBI Accession: NP_002436, NP_619729, NP_619730

UniProt: P21757