Macrophage Scavenger Receptor 1 antibody (AA 275-451)
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- Target See all Macrophage Scavenger Receptor 1 (MSR1) Antibodies
- Macrophage Scavenger Receptor 1 (MSR1)
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Binding Specificity
- AA 275-451
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Macrophage Scavenger Receptor 1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Neutralization (Neut)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. coli.
- Clone
- 5B8H4
- Isotype
- IgG1
- Top Product
- Discover our top product MSR1 Primary Antibody
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A
- Restrictions
- For Research Use only
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- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- Macrophage Scavenger Receptor 1 (MSR1)
- Alternative Name
- CD204 (MSR1 Products)
- Synonyms
- CD204 antibody, SCARA1 antibody, SR-A antibody, SRA antibody, phSR1 antibody, phSR2 antibody, MRS-A antibody, MSR antibody, MSR-A antibody, SR-AI antibody, SR-AII antibody, Scara1 antibody, Scvr antibody, MSR1 antibody, RGD1564316 antibody, macrophage scavenger receptor 1 antibody, scavenger receptor class A member 5 antibody, MSR1 antibody, Msr1 antibody, SCARA5 antibody
- Background
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Description: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Aliases: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII
- Molecular Weight
- 49.8 kDa
- Gene ID
- 4481
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