IL12B antibody (AA 196-222)

Catalog No. ABIN1538036

The Rabbit Polyclonal anti-IL12B antibody has been validated for WB. It is suitable to detect IL12B in samples from Mouse.

Quick Overview for IL12B antibody (AA 196-222) (ABIN1538036)

Target: IL12B (Interleukin 12 beta (IL12B))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB38646

Product Details anti-IL12B Antibody

Binding Specificity: AA 196-222

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Il12b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-222 amino acids from the Central region of mouse Il12b.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Mouse Il12b Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Alternative Name: Il12b

Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC (By similarity). Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Molecular Weight: 38235

Gene ID: 16160

NCBI Accession: NP_032378

UniProt: P43432

Pathways: JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation