B-Cell Linker antibody (AA 150-178)

Catalog No. ABIN1539928

This Mouse Monoclonal antibody specifically detects B-Cell Linker in WB. It exhibits reactivity toward Human.

Quick Overview for B-Cell Linker antibody (AA 150-178) (ABIN1539928)

Target: B-Cell Linker (BLNK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 520CT6-1-1

Product Details anti-B-Cell Linker Antibody

Binding Specificity: AA 150-178

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This BLNK antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human BLNK.

Isotype: IgM

Application Details

Application Notes: WB: 1:500~8000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: BLNK Antibody(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: BLNK

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 50466

Gene ID: 29760

NCBI Accession: NP_001107566, NP_001245369, NP_037446

UniProt: Q8WV28

Pathways: BCR Signaling