Peripherin antibody

Catalog No. ABIN1580457

This anti-Peripherin antibody is a Mouse Monoclonal antibody detecting Peripherin in WB, IHC, IF and ICC. Suitable for Rat and Mammalian.

Quick Overview for Peripherin antibody (ABIN1580457)

Target: Peripherin (PRPH)

Reactivity: Rat, Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 8G2

Product Details anti-Peripherin Antibody

Purification: conc. tissue culture supernatant

Isotype: IgG1

Application Details

Application Notes: We recommend trying the antibody at 1:500 for immunofluoresence and 1:5,000 of western blotting purposes.

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4°C. For safest long-term storage, maintain aliquots at -80°C or at -20°C.

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: Peripherin

Background: Peripherin is a approx. 57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. The characterization of this antibody has been published and has been on the market through many companies for several years, so many other publications make use of this reagent. The HGNC name for this protein is PRPH.