VSNL1 antibody

Catalog No. ABIN1580470

This Chicken Polyclonal antibody specifically detects VSNL1 in WB, IHC, IF and ICC. It exhibits reactivity toward Human, Mouse, Rat and Cow.

Quick Overview for VSNL1 antibody (ABIN1580470)

Target: VSNL1 (Visinin-Like 1 (VSNL1))

Reactivity: Human, Mouse, Rat, Cow

Host: Chicken

Clonality: Polyclonal

Conjugate: This VSNL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: VLP1

Product Details anti-VSNL1 Antibody

Purification: concentrated IgY preparation

Isotype: IgY

Application Details

Application Notes: This antibody is provided as an IgY preparation at about concentration of 17.8 mg/mL. The antibody solution can be used at dilutions of 1:1,000-2,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:5,000-10,000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4°C short term or -20°C long term.

Target Details for VSNL1

Target: VSNL1 (Visinin-Like 1 (VSNL1))

Alternative Name: Visinin-like protein 1

Background: Visinin was originally isolated biochemically from chicken retina as a major protein of approx. 24 kDa on SDS-PAGE. Following cloning and sequencing of visinin, several visinin like proteins were discovered by homology screening. One of these, Visinin-like protein 1 is a small Calcium binding protein which is very abundant in the nervous system and is found only in neurons, though different neurons have different levels of expression. It is particularly concentrated in cerebellar Purkinje cells, and tends to be most abundant in perikarya and dendrites. The protein was discovered independently by several groups and is therefore also sometimes known as hippocalcin-like protein 3, HLP3, HPCAL3, HUVISL1, VLP-1, VILIP and VILIP-1. The protein belongs to the large superfamily of calmodulin and paravalbumin type proteins which function by binding Calcium ions. Calcium binding alters the confomation of these proteins and allow them to interact with other binding partners, the properties of which they may alter. Visinin-like protein 1 has four EF hand domains, which are negatively charged helix-turn-helix peptides which are responsible for Calcium binding. Visinin-like protein 1 is 191 amino acids in size and has a molecular weight on SDS-PAGE of 22 kDa. The protein has recently been suggested to be a useful biomarker of Alzheimer's disease and traumatic brain injury. The HGNC name for this protein is VSNL1.