EMILIN2 antibody

Catalog No. ABIN1589876

The Mouse Monoclonal anti-EMILIN2 antibody has been validated for WB. It is suitable to detect EMILIN2 in samples from Human.

Quick Overview for EMILIN2 antibody (ABIN1589876)

Target: EMILIN2 (Elastin Microfibril Interfacer 2 (EMILIN2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EMILIN2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 828B3B3

Product Details anti-EMILIN2 Antibody

Purpose: Emilin-2 antibody

Specificity: Recombinant gC1q domain of EMILIN2

Characteristics: Chromosomal location: 18p11.3

Purification: The IgG2b/kappa fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 μm filtered solution in phosphate-buffered saline (PBS).

Immunogen: Recombinant gC1q domain of EMILIN2

Isotype: IgG2, kappa

Application Details

Application Notes: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handling Advice: Centrifuge vial prior to opening.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for EMILIN2

Target: EMILIN2 (Elastin Microfibril Interfacer 2 (EMILIN2))

Alternative Name: Emilin-2

Background: EMILIN2, FOAP-10, EMILIN-2,Emilins (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine-rich EMI domain and a conserved C-terminal gC1q-like domain. Emilin-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as Emilin-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as Emilin-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. Emilin-5 is encoded by the Emilin-3 gene and is sometimes referred to as Emilin-3. It contains the N-terminal cysteine-rich EMI domain but lacks the C-terminal gC1q-like domain. Emilin-5 is expressed in human mesenchymal stem cells and plays an important role in skeletal development.

Gene ID: 84034

NCBI Accession: NM_032048, NP_114437

UniProt: Q9BXX0