EGFL7 antibody (C-Term)

Catalog No. ABIN1589899

This Rabbit Polyclonal antibody specifically detects EGFL7 in WB, IP and ICC. It exhibits reactivity toward Human.

Quick Overview for EGFL7 antibody (C-Term) (ABIN1589899)

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGFL7 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-EGFL7 Antibody

Binding Specificity: C-Term

Purpose: VE-Statin/EGFL7 antibody

Specificity: Recombinant human EGFL-7 C-Terminus

Characteristics: Chromosomal location: 9q34.3
Produced from sera of rabbits immunised with highly pure recombinant human VE-Statin/EGFL-7.

Purification: Anti-human VE-Statin/EGFL-7 was purified by Protein-A chromatography.

Immunogen: Recombinant human EGFL7 C-Terminus

Isotype: IgG

Application Details

Application Notes: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Handling Advice: Centrifuge vial prior to opening.

Storage: 4 °C,-20 °C

Storage Comment: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Expiry Date: 24 months

Target Details for EGFL7

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Alternative Name: VE-Statin/EGFL7

Background: EGFL7, NEU1, ZNEU1, VE-STATIN, RP11-251M1.2, NOTCH4-like protein, Vascular endothelial statin,EGFL7 (VE-Statin) is an ~ 30 kDa secreted protein that contains an Emilin-like (EMI) domain (a multimerization motif), and two epidermal growth factor (EGF) domains, one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble like extracellular matrix (ECM) proteins and, thus, could incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses.

Gene ID: 51164

NCBI Accession: NM_016215, NP_057299

UniProt: Q9UHF1