ACLY antibody

Catalog No. ABIN1678575

The Rabbit Monoclonal anti-ACLY antibody (ABIN1678575) specifically detects ACLY in WB and IF. The antibody is reactive with Human samples.

Quick Overview for ACLY antibody (ABIN1678575)

Target: ACLY (ATP Citrate Lyase (ACLY))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ACLY antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ACLY Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human ACLY

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ACLY

Target: ACLY (ATP Citrate Lyase (ACLY))

Alternative Name: ACLY

Background: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],ACL, ATPCL, CLATP,Cancer,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Lipid Metabolism,Protein phosphorylation,Signal Transduction,Warburg Effect,ACLY

Molecular Weight: 120 kDa

Gene ID: 47

UniProt: P53396

Pathways: Warburg Effect