Claudin 11 antibody (AA 26-207)

Catalog No. ABIN1679255

This Rabbit Polyclonal antibody specifically detects Claudin 11 in WB. It exhibits reactivity toward Human.

Quick Overview for Claudin 11 antibody (AA 26-207) (ABIN1679255)

Target: Claudin 11 (CLDN11)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 11 Antibody

Binding Specificity: AA 26-207

Sequence: STNDWVVTCG YTIPTCRKLD ELGSKGLWAD CVMATGLYHC KPLVDILILP GYVQACRALM IAASVLGLPA ILLLLTVLPC IRMGQEPGVA KYRRAQLAGV LLILLALCAL VATIWFPVCA HRETTIVSFG YSLYAGWIGA VLCLVGGCVI LCCAGDAQAF GENRFYYTAG SSSPTHAKSA HV

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-207 of human CLDN11 (NP_005593.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Claudin 11

Target: Claudin 11 (CLDN11)

Alternative Name: CLDN11

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.,CLDN11,OSP,OTM,Immunology & Inflammation,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Oligodendrocyte marker,CLDN11

Molecular Weight: 21 kDa

Gene ID: 5010

UniProt: O75508

Pathways: Hepatitis C