Claudin 11 antibody (AA 158-207)

Catalog No. ABIN1533234

There is 1 publication for this product available. The Rabbit Polyclonal anti-Claudin 11 antibody is suitable to detect Claudin 11 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Claudin 11 antibody (AA 158-207) (ABIN1533234)

Target: Claudin 11 (CLDN11)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Claudin 11 Antibody

Binding Specificity: AA 158-207

Purpose: Claudin-11 Antibody

Specificity: Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

References for anti-Claudin 11 antibody (ABIN1533234)

Mogk, Meiwes, Shtopel, Schraermeyer, Lazarus, Kubata, Wolburg, Duszenko: "Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS." in: PLoS ONE, Vol. 9, Issue 3, pp. e91372, (2014) (PubMed).

Target Details for Claudin 11

Target: Claudin 11 (CLDN11)

Alternative Name: Claudin 11

Background:

Synonyms: CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso

Gene Name: CLDN11

Protein Name: Claudin-11

Molecular Weight: 21 kDa

Gene ID: 5010

OMIM: 601326

UniProt: O75508

Pathways: Hepatitis C