KIR3DL1 antibody (AA 22-222)

Catalog No. ABIN3015534

Product Details anti-KIR3DL1 Antibody

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Binding Specificity: AA 22-222

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR3DL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HMGGQDKPFL SAWPSAVVPR GGHVTLRCHY RHRFNNFMLY KEDRIHIPIF HGRIFQESFN MSPVTTAHAG NYTCRGSHPH SPTGWSAPSN PVVIMVTGNH RKPSLLAHPG PLVKSGERVI LQCWSDIMFE HFFLHKEGIS KDPSRLVGQI HDGVSKANFS IGPMMLALAG TYRCYGSVTH TPYQLSAPSD PLDIVVTGPY E

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-222 of human KIR3DL1 (NP_037421.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for KIR3DL1

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Alternative Name: KIR3DL1 (KIR3DL1 Products)

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.,KIR3DL1,CD158E1,KIR,KIR3DL1/S1,NKAT-3,NKAT3,NKB1,NKB1B,Immunology & Inflammation,CD markers,KIR3DL1

Molecular Weight: 38 kDa/49 kDa

Gene ID: 3811

UniProt: P43629