RAP1GAP antibody

Catalog No. ABIN1680949

This Rabbit Monoclonal antibody specifically detects RAP1GAP in WB and IF. It exhibits reactivity toward Human.

Quick Overview for RAP1GAP antibody (ABIN1680949)

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RAP1GAP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RAP1GAP Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Rap1GAP

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RAP1GAP

Target: RAP1GAP (RAP1 GTPase Activating Protein (RAP1GAP))

Alternative Name: RAP1GAP

Background: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011],RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP,Cancer,Epigenetics & Nuclear Signaling,Signal Transduction,Tumor suppressors,RAP1GAP

Molecular Weight: 95 kDa

Gene ID: 5909

UniProt: P47736