Acetyl-CoA Carboxylase alpha antibody (pSer79)

Catalog No. ABIN3020067

The Rabbit Polyclonal anti-Acetyl-CoA Carboxylase alpha antibody has been validated for WB. It is suitable to detect Acetyl-CoA Carboxylase alpha in samples from Human. There is 1 publication available.

Quick Overview for Acetyl-CoA Carboxylase alpha antibody (pSer79) (ABIN3020067)

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase alpha antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Acetyl-CoA Carboxylase alpha Antibody

Binding Specificity: pSer79

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A phospho specific peptide corresponding to residues surrounding S79 of human ACC1

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Acetyl-CoA Carboxylase alpha antibody (ABIN3020067)

Li, Zhao, Chen, Fu, Shi, Liu, Liu, Xiong, Liu, Yang, Xiao: "Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes." in: Bioorganic & medicinal chemistry, Vol. 25, Issue 24, pp. 6605-6613, (2017) (PubMed).

Target Details for Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Alternative Name: ACC1

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.,ACACA,ACAC,ACACAD,ACC,ACC1,ACCA,Endocrine & Metabolism,Lipid Metabolism,AMPK Signaling Pathway,Warburg Effect,Protein phosphorylation,ACC1

Molecular Weight: 257 kDa/259 kDa/265 kDa/269 kDa

Gene ID: 31

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect