Filamin A antibody

Catalog No. ABIN1682545

This Rabbit Monoclonal antibody specifically detects Filamin A in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Filamin A antibody (ABIN1682545)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Filamin A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Filamin A Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Filamin A

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: FLNA

Background: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009],ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,Cytoskeleton_Microfilaments,Epigenetics & Nuclear Signaling,MAPK-Erk Signaling Pathway,Protein phosphorylation,RNA Binding,Signal Transduction,FLNA

Molecular Weight: 281 kDa

Gene ID: 2316

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location