T-Bet antibody (AA 326-535)

Catalog No. ABIN1682974

This Rabbit Polyclonal antibody specifically detects T-Bet in WB. It exhibits reactivity toward Human.

Quick Overview for T-Bet antibody (AA 326-535) (ABIN1682974)

Target: T-Bet

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Bet antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-T-Bet Antibody

Binding Specificity: AA 326-535

Sequence: ENFESMYTSV DTSIPSPPGP NCQFLGGDHY SPLLPNQYPV PSRFYPDLPG QAKDVVPQAY WLGAPRDHSY EAEFRAVSMK PAFLPSAPGP TMSYYRGQEV LAPGAGWPVA PQYPPKMGPA SWFRPMRTLP MEPGPGGSEG RGPEDQGPPL VWTEIAPIRP ESSDSGLGEG DSKRRRVSPY PSSGDSSSPA GAPSPFDKEA EGQFYNYFPN

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human TBX21 (NP_037483.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for T-Bet

Target: T-Bet

Alternative Name: TBX21

Background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.,TBX21,T-PET,T-bet,TBET,TBLYM,T-box 21,Epigenetics & Nuclear Signaling,Transcription Factors,Immunology & Inflammation,Stem Cells,Hematopoietic Progenitors,TBX21

Molecular Weight: 58 kDa

Gene ID: 30009

UniProt: Q9UL17