TPSAB1 antibody (AA 19-210)

Catalog No. ABIN1683115

This anti-TPSAB1 antibody is a Rabbit Polyclonal antibody detecting TPSAB1 in WB. Suitable for Human.

Quick Overview for TPSAB1 antibody (AA 19-210) (ABIN1683115)

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPSAB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPSAB1 Antibody

Binding Specificity: AA 19-210

Sequence: APAPGQALQR VGIVGGQEAP RSKWPWQVSL RVHGPYWMHF CGGSLIHPQW VLTAAHCVGP DVKDLAALRV QLREQHLYYQ DQLLPVSRII VHPQFYTAQI GADIALLELE EPVNVSSHVH TVTLPPASET FPPGMPCWVT GWGDVDNDER LPPPFPLKQV KVPIMENHIC DAKYHLGAYT GDDVRIVRDD ML

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-210 of human TPSAB1 (NP_003285.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPSAB1

Target: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Alternative Name: TPSAB1

Background: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.,TPSAB1,TPS1,TPS2,TPSB1,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,TPSAB1

Molecular Weight: 29 kDa/30 kDa

Gene ID: 7177

UniProt: Q15661