SUMO2 antibody (AbBy Fluor® 488)

Catalog No. ABIN1696109

The Rabbit Polyclonal anti-SUMO2 antibody has been validated for IF (p). It is suitable to detect SUMO2 in samples from Human, Rat and Mouse.

Quick Overview for SUMO2 antibody (AbBy Fluor® 488) (ABIN1696109)

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUMO2 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SUMO2 Antibody (AbBy Fluor® 488)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Sumo 2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C

Expiry Date: 12 months

Target Details for SUMO2

Target: SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

Alternative Name: Sumo 2

Background:

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease

Synonyms: Small ubiquitin-related modier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A, SUMO2_HUMAN.

Gene ID: 6613

Pathways: Methionine Biosynthetic Process