Lethal (2) I16 (L(2)I16) (AA 701-785) antibody (AbBy Fluor® 555)

Catalog No. ABIN1696416

The AbBy Fluor® 555-conjugated Rabbit Polyclonal anti-Lethal (2) I16 antibody (ABIN1696416) specifically detects Lethal (2) I16 in WB, IF (cc) and IF (p). The antibody is reactive with Mouse samples.

Quick Overview for Lethal (2) I16 (L(2)I16) (AA 701-785) antibody (AbBy Fluor® 555) (ABIN1696416)

Target: Lethal (2) I16 (L(2)I16)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Binding Specificity: AA 701-785

Cross-Reactivity: Mouse

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IFI16

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Lethal (2) I16 (L(2)I16)

Alternative Name: I16

Background:

Synonyms: I16, Gamma interferon inducible protein 16, Gamma-interferon-inducible protein i16, IF16_HUMAN, i204, NGIP1, interferon activated gene 204, Interferon gamma induced protein I 16, Interferon gamma inducible protein 16, Interferon-inducible myeloid dferentiation transcriptional activator, p204, PYHIN2.

Background: IFI16 is a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID: 3428

UniProt: Q16666