GCNT7 antibody (AA 241-430) (Biotin)

Catalog No. ABIN1700309

The Rabbit Polyclonal anti-GCNT7 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect GCNT7 in samples from Human.

Quick Overview for GCNT7 antibody (AA 241-430) (Biotin) (ABIN1700309)

Target: GCNT7 (Glucosaminyl (N-Acetyl) Transferase Family Member 7 (GCNT7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCNT7 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GCNT7 Antibody (Biotin)

Binding Specificity: AA 241-430

Predicted Reactivity: Human,Mouse,Rat,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCNT7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GCNT7

Target: GCNT7 (Glucosaminyl (N-Acetyl) Transferase Family Member 7 (GCNT7))

Alternative Name: GCNT7

Background:

Synonyms: 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 7, Beta-1, Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7, C20orf105, GCNT, GCNT7, GCNT7_HUMAN, glucosaminyl N-acetyl transferase family member 7.

Background: Belonging to the glycosyltransferase 14 family, GCNT7, also known as Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7, is a 430 amino acid glycosyltransferase that is localized to the Golgi apparatus. Other members of this family include GCNT1, GCNT2, GCNT3, GCNT4 and GCNT6. GCNT1 has been shown to play an important regulatory role in the biosynthesis of mucin-type O-glycans, which serve as ligands in cell adhesion. Specifically, GCNT1 expression in leukocytes regulates the synthesis of core 2 O-glycans that carry sialyl-Lewis x (sLex) oligosaccharides, which confer high affinity binding to Selectin proteins. Since downregulation of Selectin ligand expression has been shown to inhibit tissue infiltration, glycosyltransferase 14 family members represent potential drug targets for the treatment of inflammatory disorders and other pathologies involving Selectin proteins.

Gene ID: 140687