DYX1C1 antibody (AA 51-120) (Biotin)

Catalog No. ABIN1700546

The Rabbit Polyclonal anti-DYX1C1 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect DYX1C1 in samples from Mouse and Rat.

Quick Overview for DYX1C1 antibody (AA 51-120) (Biotin) (ABIN1700546)

Target: DYX1C1 (Dyslexia Susceptibility 1 Candidate 1 (DYX1C1))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYX1C1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-DYX1C1 Antibody (Biotin)

Binding Specificity: AA 51-120

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Chicken,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYX1C1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DYX1C1

Target: DYX1C1 (Dyslexia Susceptibility 1 Candidate 1 (DYX1C1))

Alternative Name: DYX1C1

Background:

Synonyms: Dyslexia susceptibility 1 candidate 1, Dyslexia susceptibility 1 candidate gene 1 protein, DYX1, DYX1C1, DYXC1, DYXC1_HUMAN, EKN1, FLJ37882, MGC70618, RD.

Background: The gene encoding DYX1C1 maps in the 15q21 region, which is disrupted by a translocation t(2,15)(q11,q21) and segregates with dyslexia. Two sequence changes in DYX1C1, including one involving the translation initiation sequence and an Elk-1 transcription factor binding site (-3G --> A) and a codon (1249G --> T), introduce a premature stop codon and truncate the protein by 4 amino acids. DYX1C1 encodes a nuclear tetratricopeptide repeat domain protein that is dynamically regulated in brain. In human brain, DYX1C1 protein localizes to a fraction of cortical neurons and white matter glial cells. It is also expressed in lung, kidney and testis.

Gene ID: 161582

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling