GEMIN7 antibody (AA 21-120) (Biotin)

Catalog No. ABIN1700552

The Rabbit Polyclonal anti-GEMIN7 antibody is suitable to detect GEMIN7 in samples from Human and Rat. It has been validated for ELISA, IHC (fro) and IHC (p).

Quick Overview for GEMIN7 antibody (AA 21-120) (Biotin) (ABIN1700552)

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN7 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GEMIN7 Antibody (Biotin)

Binding Specificity: AA 21-120

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gemin 7

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GEMIN7

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Alternative Name: Gemin 7

Background:

Synonyms: SIP3, Gemin7, Gemin-7, GEMI7_HUMAN.

Background: Gemin7 is a 131 amino acid protein encoded by the mouse gene Gemin7. Gemin7, along with Gemin6, is a significant component of the the large multiprotein human SMN complex. The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. The survival of motor neurons (SMN) protein, a product of the disease gene of the common neurodegenerative disease, spinal muscular atrophy, is also part of the SMN complex. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. The Gemin6/Gemin7 complex binds to Sm proteins and might help organize Sm proteins for formation of Sm rings on snRNA targets.

Gene ID: 79760

Pathways: Ribonucleoprotein Complex Subunit Organization