KNDC1 antibody (AA 1601-1749) (Biotin)

Catalog No. ABIN1700782

This Rabbit Polyclonal antibody specifically detects KNDC1 in WB, ELISA, IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for KNDC1 antibody (AA 1601-1749) (Biotin) (ABIN1700782)

Target: KNDC1 (Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 (KNDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNDC1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KNDC1 Antibody (Biotin)

Binding Specificity: AA 1601-1749

Predicted Reactivity: Human,Mouse,Rat,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KNDC1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for KNDC1

Target: KNDC1 (Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 (KNDC1))

Alternative Name: KNDC1

Background:

Synonyms: Cerebral protein 9, FLJ25027, hucep-9, KIAA1768, Kinase non-catalytic C-lobe domain-containing protein 1, KIND domain-containing protein 1, KNDC1, Protein very KIND, Ras-GEF domain-containing family member 2, RASGEF2, VKIND, VKIND_HUMAN, bB439H18.3, C10orf23.

Background: KNDC1 is a 1,749 amino acid protein that contains two KIND domains and an N-terminal Ras-GEF domain. Expressed in the cerebral cortex, KNDC1 is a likely guanine nucleotide exchange factor (GEF). Existing as six alternatively spliced isoforms, the gene encoding KNDC1 maps to human chromosome 10q26.3 and mouse chromosome 7 F4. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5 % of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman?s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Gene ID: 85442