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VAV3 antibody (pTyr141) (Biotin)

This Rabbit Polyclonal antibody specifically detects VAV3 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse and Rat.
Catalog No. ABIN1700908

Quick Overview for VAV3 antibody (pTyr141) (Biotin) (ABIN1700908)

Target

See all VAV3 Antibodies
VAV3 (Vav 3 Oncogene (VAV3))

Reactivity

  • 54
  • 30
  • 23
  • 1
Mouse, Rat

Host

  • 67
  • 1
Rabbit

Clonality

  • 66
  • 2
Polyclonal

Conjugate

  • 28
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This VAV3 antibody is conjugated to Biotin

Application

  • 41
  • 26
  • 26
  • 25
  • 12
  • 8
  • 7
  • 6
  • 4
  • 4
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Binding Specificity

    • 15
    • 14
    • 11
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr141

    Cross-Reactivity

    Mouse, Rat

    Predicted Reactivity

    Human,Cow,Sheep,Horse

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C for 12 months.

    Expiry Date

    12 months
  • Target

    VAV3 (Vav 3 Oncogene (VAV3))

    Alternative Name

    VAV3

    Background

    Synonyms: VAV3phospho Y141, Guanine nucleotide exchange factor VAV3, Protein vav 3, Protein vav3, VAV 3, Vav 3 guanine nucleotide exchange factor, VAV 3 oncogene, VAV 3 protein, VAV-3, Vav3, VAV3 oncogene, VAV3 protein, VAV3_HUMAN.

    Background: The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation. Vav3, like Vav (also known as Vav1 or p95Vav), undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, and subsequently interacts with 2 adaptor molecules, SLP76 and 3BP2. Following these events, however, the paths of Vav and Vav3 diverge, Vav affects IL-2 promotor activity, while Vav3 impacts gene transcription linked to serum response element (SRE). Furthermore, Vav3 expression follows a cell cycle-dependent pattern, with transient upregulation occuring during mitosis. Encforced Vav3 expression leads to the appearance of multinucleate cells, implicating a role for Vav3 in the control of cytokinesis.

    Gene ID

    10451

    Pathways

    Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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