Glutaredoxin 2 antibody (AA 101-164) (Biotin)

Catalog No. ABIN1701049

This Rabbit Polyclonal antibody specifically detects Glutaredoxin 2 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human and Rat.

Quick Overview for Glutaredoxin 2 antibody (AA 101-164) (Biotin) (ABIN1701049)

Target: Glutaredoxin 2 (GRX2)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Glutaredoxin 2 Antibody (Biotin)

Binding Specificity: AA 101-164

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glutaredoxin 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Alternative Name: Glutaredoxin 2

Background:

Synonyms: GRX2, CGI-133, Glutaredoxin-2, mitochondrial, GLRX2

Background: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Gene ID: 51022

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis