GALE antibody (AA 21-120) (Biotin)

Catalog No. ABIN1701447

This anti-GALE antibody is a Rabbit Polyclonal antibody detecting GALE in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse.

Quick Overview for GALE antibody (AA 21-120) (Biotin) (ABIN1701447)

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALE antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GALE Antibody (Biotin)

Binding Specificity: AA 21-120

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GALE/Galactowaldenase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GALE

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Alternative Name: GALE/Galactowaldenase

Background:

Synonyms: FLJ95174, FLJ97302, Galactose 4 epimerase UDP, Galactowaldenase, galE, GALE_HUMAN, OTTHUMP00000002991, OTTHUMP00000002994, OTTHUMP00000037931, OTTHUMP00000044857, SDR1E1, short chain dehydrogenase/reductase family 1E member 1, UDP galactose 4 epimerase, UDP glucose 4 epimerase, UDP-galactose 4-epimerase, UDP-glucose 4-epimerase.

Background: GALE is a 348 amino acid protein that functions as the third enzyme in the Leloir pathway of galactose metabolism. A member of the sugar epimerase family, GALE exists as a homodimer, binds FAD as a cofactor and catalyzes the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine and UDP-glucose to UDP-galactose. The gene encoding GALE maps to human chromosome 1p36.11 and mutations in this gene lead to the development of complex disorder known as epimerase-deficiency galactosemia (EDG) or galactosemia type 3, which is characterized by mental retardation, liver damage, cataracts and deafness.

Gene ID: 2582

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process