HCP5 antibody (AA 1-80) (Cy3)

Catalog No. ABIN1701837

This anti-HCP5 antibody is a Rabbit Polyclonal antibody detecting HCP5 in WB, IF (cc) and IF (p). Suitable for Human.

Quick Overview for HCP5 antibody (AA 1-80) (Cy3) (ABIN1701837)

Target: HCP5 (HLA Complex P5 (Non-Protein Coding) (HCP5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCP5 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HCP5 Antibody (Cy3)

Binding Specificity: AA 1-80

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HCP5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HCP5

Target: HCP5 (HLA Complex P5 (Non-Protein Coding) (HCP5))

Alternative Name: Hcp5

Background:

Synonyms: HLA class I histocompatibility antigen protein P5, HLA complex protein P5, Protein P5 1, HCP5_HUMAN.

Background: HCP5 is a region present on chromosome 6p21.3 that is characterized by multiple duplicated gene families. HCP5 (HLA class I histocompatibility antigen protein P5), also known as P5-1, is a 132 amino acid protein that is encoded by a gene mapping to human chromosome 6p21.33. Localizing within the MHC class I region, HCP5 is not structurally related to other MHC class I genes, but does have high sequence similarity with HERV-L and HERV-16. HCP5 also has high sequence homology to retroviral Pol genes, making it a possible candidate for interaction with HIV-1 through an antisense mechanism that prevents retrovirus transcription. Single-nucleotide polymorphisms (SNPs) to the region of the HCP5 gene that corresponds with HLA-B has been linked to a lower HIV-1 viral set point. HCP5 is highly expressed in lymphoid tissues, spleen and activated lymphocytes, as well as B-cell and natural killer (NK) cell lines.